Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.35 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343949 | 0.81 | — | — | |
| SCHEMBL10148986 | 0.80 | RXRA (0.44) | KDM4EMEN1NPC1ALDH1A1POLB | |
| SCHEMBL10149042 | 0.80 | RXRA (0.48) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL10148487 | 0.72 | KDM4E (0.38) | KDM4EALDH1A1MAPTPKMHTT | |
| SCHEMBL10123761 | 0.70 | — | — | |
| SCHEMBL10123685 | 0.69 | BCL2 (0.45) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL2998259 | 0.65 | ALDH1A1 (0.60) | KDM4EMEN1ALDH1A1POLBGAA | |
| SCHEMBL10148477 | 0.64 | RXRA (0.47) | KDM4EMEN1NPC1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8436476 | 0.63 | ALDH1A1 (0.58) | KDM4EMEN1ALDH1A1POLBGAA | |
| SCHEMBL25125893 | 0.60 | TP53 (0.52) | KDM4EALDH1A1KMT2ARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415771-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |