Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10148380 | 0.83 | KDM4E (0.47) | RXRARXRBKDM4EALDH1A1HPGD | |
| SCHEMBL10123699 | 0.81 | RXRA (0.45) | RXRARXRBRXRGSRD5A2MAPK1 | |
| SCHEMBL10148986 | 0.80 | RXRA (0.44) | RXRARXRBMAP4K4SRD5A2KDM4E | |
| SCHEMBL10148371 | 0.80 | KDM4E (0.36) | RXRARXRBRXRGMAP4K4SRD5A2 | |
| SCHEMBL10148487 | 0.72 | KDM4E (0.38) | RXRARXRBMAP4K4KDM4EALDH1A1 | |
| SCHEMBL18587126 | 0.71 | MAP4K4 (0.59) | RXRARXRBRXRGMAP4K4SRD5A2 | |
| SCHEMBL10123803 | 0.69 | RXRA (0.45) | RXRARXRBRXRGSRD5A2TDP1 | |
| SCHEMBL10123807 | 0.68 | GABRA1 (0.40) | RXRARXRBRXRG | |
| SCHEMBL14176107 | 0.68 | KDM4E (0.46) | RXRARXRBRXRGMAP4K4SRD5A2 | |
| SCHEMBL505133 | 0.67 | SRD5A2 (0.77) | RXRARXRBRXRGMAP4K4SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415771-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |