Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149551 | 0.83 | XDH (0.40) | KDM4EALDH1A1MAPT | |
| SCHEMBL10123682 | 0.81 | NR3C2 (0.40) | — | |
| SCHEMBL10148986 | 0.77 | RXRA (0.44) | KDM4ELMNAHSD17B10RXRARXRB | |
| SCHEMBL10148371 | 0.72 | KDM4E (0.36) | KDM4ELMNAHSD17B10RXRARXRB | |
| SCHEMBL10149042 | 0.72 | RXRA (0.48) | KDM4EHSD17B10RXRARXRBALDH1A1 | |
| SCHEMBL10148477 | 0.69 | RXRA (0.47) | KDM4ELMNAHSD17B10RXRARXRB | |
| SCHEMBL10123781 | 0.67 | NR3C2 (0.39) | — | |
| SCHEMBL13522875 | 0.65 | ALDH1A1 (0.63) | KDM4ELMNAHSD17B10RXRARXRB | |
| SCHEMBL3643353 | 0.65 | KDM4E (0.66) | KDM4ELMNAHSD17B10RXRARXRB | |
| SCHEMBL385343 | 0.63 | LMNA (0.53) | KDM4ELMNAHSD17B10RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415771-A1 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |