SCHEMBL10149598

SCHEMBL10149598

CC(C)/C=C/c1cnc[nH]1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AOC1 P19801 2/20 0.50
BLM P54132 2/20 0.48
KDM4E B2RXH2 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CYP3A4 P08684 1/20 0.48
TSHR P16473 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HRH3 Q9Y5N1 8/20 0.44
ALDH1A1 P00352 3/20 0.38
FKBP5 Q13451 1/20 0.38
HRH4 Q9H3N8 4/20 0.37
GLA P06280 1/20 0.37
CYP1A2 P05177 1/20 0.37
NFKB1 P19838 1/20 0.37
THPO P40225 1/20 0.37
LMNA P02545 1/20 0.36
APEX1 P27695 1/20 0.36
ADAMTS5 Q9UNA0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19059633 0.81 KDM4E (0.55) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL25101013 0.72 KDM4E (0.64) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL2600071 0.71 AOC1 (0.50) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL16317364 0.71 AOC1 (0.50) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL27168208 0.69 HRH3 (0.44) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL4965314 0.68
SCHEMBL1997770 0.67
SCHEMBL5238058 0.67 AOC1 (0.50) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL19558473 0.67 AOC1 (0.46) AOC1BLMKDM4ENPSR1CYP3A4
SCHEMBL9111778 0.67 AOC1 (0.50) AOC1BLMKDM4ENPSR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2018-01-11 US disclosed
US-9844540-B2 Combination therapies for treating cancer REDHILL BIOPHARMA LTD. (IL) 2017-12-19 US disclosed
US-9663471-B2 Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORPORATION (US) 2017-05-30 US disclosed
US-20170095460-A1 COMBINATION THERAPIES FOR TREATING CANCER REDHILL BIOPHARMA LTD. (IL) 2017-04-06 US disclosed
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2014-09-11 US disclosed
US-20140256780-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORPORATION (US) 2014-09-11 US disclosed
US-8772326-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity Anigion Biomedica Corp. (US) 2014-07-08 US disclosed
US-20140171419-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2014-06-19 US disclosed
US-8580834-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2013-11-12 US disclosed
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP 2013-07-25 US disclosed
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-07-26 US disclosed
US-8193177-B2 Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases ANGION BIOMEDICA CORP. (US) 2012-06-05 US disclosed
US-20110230407-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2011-09-22 US disclosed
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2011-07-28 US disclosed
US-7879898-B1 treating a chronic obstructive pulmonary disease using modulators of HGF/SF activity; for example, 3-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one; emphysema ANGION BIOMEDICA CORP. (US) 2011-02-01 US disclosed
US-20100256117-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES ANGION BIOMEDICA CORP. 2010-10-07 US disclosed
US-20080015243-A1 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. 2008-01-17 US disclosed
US-7265112-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2007-09-04 US disclosed
US-7250437-B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2007-07-31 US disclosed
US-7192976-B2 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity ANGION BIOMEDICA CORPORATION (US) 2007-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC AOC1 2524/4885BLM 2407/4885KDM4E 3771/4885
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC AOC1 2923/4885BLM 1653/4885KDM4E 4796/4885
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC AOC1 2923/4885BLM 1653/4885KDM4E 4796/4885
US-20080015243-A1 Small molecule modulators of hepatocyte growth factor (scatter factor) activity HGF, HDGF, MET AOC1 4191/4885BLM 3118/4885KDM4E 4429/4885
US-20110230407-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA HGF, HGFAC, HDGF AOC1 3467/4885BLM 1563/4885KDM4E 4833/4885
US-20100256117-A1 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES HGF, HDGF, HGFAC AOC1 2079/4885BLM 1645/4885KDM4E 4513/4885
US-20140171419-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, MET AOC1 3253/4885BLM 4050/4885KDM4E 3736/4885
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC AOC1 2923/4885BLM 1653/4885KDM4E 4796/4885
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC AOC1 3097/4885BLM 1938/4885KDM4E 4752/4885
US-20170095460-A1 COMBINATION THERAPIES FOR TREATING CANCER KRAS, ACE, TPMT AOC1 1111/4885BLM 3840/4885KDM4E 293/4885
US-20140256780-A1 PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, MET AOC1 3106/4885BLM 3552/4885KDM4E 4526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.