Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.61 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.61 |
| ▸ | GABRP | O00591 | 1/20 | 0.61 |
| ▸ | GABRD | O14764 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.61 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.61 |
| ▸ | GABRE | P78334 | 1/20 | 0.61 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165803 | 0.89 | OPRK1 (0.65) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL10149039 | 0.86 | OPRK1 (0.61) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL5361219 | 0.82 | TP53 (0.72) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL607255 | 0.82 | LMNA (0.81) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL14506598 | 0.80 | GABRA1 (0.55) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11445148 | 0.79 | OPRK1 (0.70) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL5042664 | 0.78 | GABRA1 (0.65) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL607167 | 0.78 | TP53 (0.64) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL5354863 | 0.77 | TP53 (0.71) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL21442 | 0.77 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2007053193-A2 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-10 | — | — | WO | disclosed |