Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.65 |
| ▸ | GABRP | O00591 | 1/20 | 0.65 |
| ▸ | GABRD | O14764 | 1/20 | 0.65 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.65 |
| ▸ | ALB | P02768 | 1/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.65 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.65 |
| ▸ | GABRE | P78334 | 1/20 | 0.65 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.65 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10149039 | 0.89 | OPRK1 (0.61) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL14506598 | 0.89 | GABRA1 (0.55) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL10149903 | 0.89 | OPRK1 (0.61) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11445148 | 0.82 | OPRK1 (0.70) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL29362687 | 0.79 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL1019217 | 0.79 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL16922183 | 0.79 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL21442 | 0.79 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL9278054 | 0.79 | GABRA1 (1.00) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL10165801 | 0.79 | OPRK1 (0.52) | OPRK1GABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077805-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | US | disclosed |
| US-7994313-B2 | Unsolvated benzodiazepine compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-08-09 | — | — | US | disclosed |
| US-20090275099-A1 | Methods and compositions for treating diseases and conditions associated with mitochondrial function | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090253686-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-10-08 | — | — | US | disclosed |
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-11-27 | — | — | US | disclosed |
| US-20070043033-A1 | Unsolvated benzodiazepine compositions and methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | BAX, BAD, GABRB3 | OPRK1 111/4885GABRA1 12/4885GABRA5 8/4885 |
| US-20090275099-A1 | Methods and compositions for treating diseases and conditions associated with mitochondrial function | ATP5F1A, ATP5MF, MT-ATP6 | OPRK1 4655/4885GABRA1 4515/4885GABRA5 4554/4885 |
| US-20120077805-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | GABRA5, GABRA3, GABRA6 | OPRK1 46/4885GABRA1 6/4885GABRA5 1/4885 |
| US-20070043033-A1 | Unsolvated benzodiazepine compositions and methods | GABRA5, GABRA3, GABRA6 | OPRK1 46/4885GABRA1 6/4885GABRA5 1/4885 |
| US-20090253686-A1 | UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS | GABRA5, GABRA3, GABRA6 | OPRK1 46/4885GABRA1 6/4885GABRA5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.