Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13392155 | 0.89 | LMNA (0.39) | LMNAKDM4EKMT2AALDH1A1CYP1A2 | |
| SCHEMBL765338 | 0.83 | LMNA (0.39) | LMNAALOX15KDM4EKMT2AALDH1A1 | |
| SCHEMBL14260258 | 0.82 | KDM4E (0.38) | LMNAKDM4EKMT2AALDH1A1ADRB2 | |
| SCHEMBL14260264 | 0.79 | LMNA (0.38) | LMNACYP2C19CYP1A2 | |
| SCHEMBL13392162 | 0.78 | LMNA (0.40) | LMNAALOX15KDM4EKMT2AALDH1A1 | |
| SCHEMBL764884 | 0.78 | ADRB2 (0.55) | LMNATAAR1ADRB2ADRB1 | |
| SCHEMBL764855 | 0.77 | LMNA (0.39) | LMNATAAR1CYP1A2ADRB2ADRB1 | |
| SCHEMBL13894250 | 0.76 | LMNA (0.55) | LMNAKDM4EKMT2AALDH1A1CYP1A2 | |
| SCHEMBL10150235 | 0.74 | LMNA (0.39) | LMNAALOX15KMT2ACYP2C19ADRB2 | |
| SCHEMBL10150183 | 0.72 | ALDH1A1 (0.36) | LMNAALOX15KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431380-A2 | Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders | Tranzyme Pharma, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |