Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 4/20 | 0.54 |
| ▸ | HTR1B | P28222 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | HTR1D | P28221 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180904 | 0.88 | KDM4E (0.56) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL8171524 | 0.85 | PKM (0.61) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL4854372 | 0.84 | HTR2A (0.63) | ICMTMAPTMAPK1HTR2AKDM4E | |
| SCHEMBL2542080 | 0.80 | HTR1A (0.76) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL9950019 | 0.80 | ALDH1A1 (0.62) | ICMTHTR1DMAPTKDM4EMEN1 | |
| SCHEMBL12721122 | 0.78 | KDM4E (0.71) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL15678386 | 0.77 | HTR1B (0.57) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL17034508 | 0.77 | HTT (0.53) | HTR1BMAPT | |
| SCHEMBL10123846 | 0.76 | ICMT (0.66) | ICMTHTR1DMAPTHTR2ANPSR1 | |
| SCHEMBL18103513 | 0.76 | HTR1B (0.50) | HTR1BHTR1AHTR1DMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655372-B1 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-8470786-B2 | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | ARQULE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2012088491-A2 | PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARQULE, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165278-A1 | Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same | DHPS, PDCD5, DPYD | ICMT 3059/4885HTR1B 3329/4885HTR1A 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.