Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646780 | 0.87 | TP53 (0.38) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL10151417 | 0.82 | MAPT (0.38) | TP53RAB9ANPC1MAPTMEN1 | |
| SCHEMBL10151672 | 0.82 | RAB9A (0.44) | RAB9ANPC1MAPTPOLBMEN1 | |
| SCHEMBL10151409 | 0.82 | ALDH1A1 (0.40) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL647969 | 0.80 | NPC1 (0.38) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL10151390 | 0.77 | RAB9A (0.42) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL10151385 | 0.76 | NPC1 (0.36) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL13729224 | 0.74 | RAB9A (0.40) | TP53RAB9ANPC1MITFGAA | |
| SCHEMBL646756 | 0.74 | EPHX2 (0.36) | TP53RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL649242 | 0.73 | RAB9A (0.38) | TP53RAB9ANPC1MITFGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |