Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BMI1 | P35226 | 2/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645672 | 0.87 | CRACR2A (0.41) | ALDH1A1CRACR2ALMNAPOLBGRM5 | |
| SCHEMBL10151287 | 0.83 | BMI1 (0.34) | LMNAKDM4ENPC1TP53GAA | |
| SCHEMBL10151672 | 0.82 | RAB9A (0.44) | POLBGRM5KDM4ENPC1RAB9A | |
| SCHEMBL10151674 | 0.82 | TP53 (0.38) | LMNAPOLBGRM5KDM4EUSP2 | |
| SCHEMBL646789 | 0.81 | CRACR2A (0.41) | ALDH1A1CRACR2ALMNAPOLBGRM5 | |
| SCHEMBL10151390 | 0.76 | RAB9A (0.42) | ALDH1A1POLBKDM4ENPC1MITF | |
| SCHEMBL646772 | 0.75 | CRACR2A (0.40) | ALDH1A1CRACR2ALMNAPOLBNPC1 | |
| SCHEMBL10151385 | 0.73 | NPC1 (0.36) | ALDH1A1GRM5KDM4ENPC1MITF | |
| SCHEMBL645712 | 0.73 | POLB (0.41) | ALDH1A1CRACR2ALMNAPOLBKDM4E | |
| SCHEMBL10151679 | 0.72 | STIM1 (0.37) | LMNANPC1TP53GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |