SCHEMBL10153203

SCHEMBL10153203

CCCc1ccc(-c2ccc(-c3ccc(-c4ccc(C5CO5)c(F)c4F)cc3)c(F)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.38
RARA P10276 1/20 0.35
RARG P13631 1/20 0.35
MPL P40238 3/20 0.34
GRM2 Q14416 2/20 0.34
HTR2A P28223 1/20 0.34
MCL1 Q07820 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
BRD4 O60885 1/20 0.32
CHKA P35790 1/20 0.32
NPC1 O15118 1/20 0.30
TP53 P04637 1/20 0.30
PKM P14618 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HSD17B10 Q99714 1/20 0.30
S1PR1 P21453 1/20 0.30
S1PR3 Q99500 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12907934 0.93 RARB (0.37) RARBMPLGRM2HTR2ABRD4
SCHEMBL3582636 0.93 MPL (0.35) RARBMPLMCL1BRD4CHKA
SCHEMBL13263302 0.92 RARB (0.48) RARBRARARARGMPLHSD17B10
SCHEMBL3582651 0.91 MPL (0.36) RARBMPLBRD4CHKAS1PR1
SCHEMBL9015779 0.91 RARB (0.33) RARBRARARARGMPLMCL1
SCHEMBL9015903 0.87 NAAA (0.30)
SCHEMBL12821152 0.86 BRD4 (0.34) RARBRARARARGMPLMCL1
SCHEMBL12821228 0.85 MPL (0.33) RARBMPLBRD4
SCHEMBL13586379 0.85 BRD4 (0.39) RARBMPLGRM2HTR2ABRD4
SCHEMBL12907011 0.85 BRD4 (0.33) RARBMPLBRD4CHKAS1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8187494-B2 Four- or five-ring liquid crystal compound having lateral fluorine, liquid crystal composition, and liquid crystal display device JNC CORPORATION (JP) 2012-05-29 US disclosed
US-20100309402-A1 FOUR- OR FIVE-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE CHISSO CORPORATION (JP) 2010-12-09 US disclosed
EP-2206695-A1 TETRA- OR PENTA-CYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT Chisso Corporation (JP) 2010-07-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100309402-A1 FOUR- OR FIVE-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE KIF23, HCN3, FZD7 RARB 3042/4885RARA 2237/4885RARG 2967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.