Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.38 |
| ▸ | HTR3B | O95264 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153360 | 0.81 | AHR (0.35) | TSHRITGB3ITGAVCYP3A4ALDH1A1 | |
| SCHEMBL14459257 | 0.79 | MAPT (0.50) | TSHRHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL85152 | 0.76 | MAPT (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7092582 | 0.71 | ALDH1A1 (0.38) | TSHRERN1TPMTMEN1ALDH1A1 | |
| SCHEMBL14459252 | 0.71 | KMT2A (0.58) | TSHRHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13590027 | 0.71 | S100B (0.50) | TP53MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL13590019 | 0.68 | ALDH1A1 (0.37) | CYP3A4MEN1ALDH1A1MAPTRECQL | |
| SCHEMBL14459432 | 0.67 | KMT2A (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10153362 | 0.67 | ITGB3 (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| 1,3,5-Trichlorobenzene SCHEMBL27517784 | 0.67 | TSHR (0.61) | TSHRERN1TPMTTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | TSHR 1865/4885HTR3E 3836/4885HTR3B 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.