Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21374046 | 0.86 | CHRNB2 (0.47) | CHRNB2CHRNA4 | |
| SCHEMBL10763885 | 0.86 | ALDH1A1 (0.43) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| SCHEMBL7094788 | 0.86 | GBA1 (0.40) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL2822843 | 0.85 | LTA4H (0.57) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| SCHEMBL643358 | 0.85 | LTA4H (0.57) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| SCHEMBL1367956 | 0.85 | LTA4H (0.57) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| SCHEMBL18110705 | 0.85 | LTA4H (0.57) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| Hydrochloric Acid SCHEMBL18111693 | 0.83 | LTA4H (0.56) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| Bromide SCHEMBL1363188 | 0.83 | LTA4H (0.56) | SIGMAR1CHRNB2CHRNA4LTA4H | |
| Bromide SCHEMBL5857053 | 0.83 | LTA4H (0.56) | SIGMAR1CHRNB2CHRNA4LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275017-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275017-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8778957-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778957-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120010193-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010193-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275017-A1 | CGRP RECEPTOR ANTAGONISTS | BDKRB1, CALCRL, BDKRB2 | SIGMAR1 657/4885CHRNB2 119/4885CHRNA4 144/4885 |
| US-20120010193-A1 | CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CALCRL | SIGMAR1 640/4885CHRNB2 111/4885CHRNA4 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.