Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.47 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342526 | 0.86 | BRAF (0.46) | CHRNB2CHRNA4BRAFCHRNB4CHRNA3 | |
| SCHEMBL10153638 | 0.86 | SIGMAR1 (0.46) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL2830200 | 0.85 | BRAF (0.45) | CHRNB2CHRNA4BRAFCHRNB4CHRNA3 | |
| SCHEMBL7094788 | 0.82 | GBA1 (0.40) | CHRNB2CHRNA4GBA1 | |
| SCHEMBL10763885 | 0.82 | ALDH1A1 (0.43) | CHRNB2CHRNA4GBA1 | |
| SCHEMBL643358 | 0.71 | LTA4H (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL18110705 | 0.71 | LTA4H (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL2822843 | 0.71 | LTA4H (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL1367956 | 0.71 | LTA4H (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL5038432 | 0.71 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | CHRNB2 793/4885CHRNA4 654/4885TRPV6 2337/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | CHRNB2 418/4885CHRNA4 369/4885TRPV6 2598/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | CHRNB2 418/4885CHRNA4 369/4885TRPV6 2598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.