Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 17/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689118 | 0.86 | PKM (0.64) | PKMALDH1A1IDO1 | |
| SCHEMBL14089190 | 0.83 | PKM (0.60) | PKMALDH1A1L3MBTL1IDO1PKLR | |
| SCHEMBL2586153 | 0.81 | PKM (1.00) | PKMALDH1A1L3MBTL1PKLR | |
| SCHEMBL30114411 | 0.80 | PKM (0.60) | PKMALDH1A1IDO1PKLR | |
| SCHEMBL2586707 | 0.80 | PKM (0.60) | PKMALDH1A1IDO1PKLR | |
| SCHEMBL4712443 | 0.80 | PKM (0.57) | PKMALDH1A1L3MBTL1IDO1PKLR | |
| SCHEMBL17980375 | 0.80 | CA12 (0.58) | PKMALDH1A1L3MBTL1IDO1PKLR | |
| SCHEMBL2585274 | 0.79 | PKM (1.00) | PKMALDH1A1 | |
| SCHEMBL2593652 | 0.79 | LMNA (0.58) | PKMALDH1A1L3MBTL1 | |
| SCHEMBL1711251 | 0.79 | PKM (1.00) | PKMALDH1A1L3MBTL1PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708267-B2 | Activators of human pyruvate kinase | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150183744-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | US HEALTH (US) | 2015-07-02 | — | — | US | disclosed |
| US-20150183744-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | US HEALTH (US) | 2015-07-02 | — | — | US | disclosed |
| US-20130109672-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (US) | 2013-05-02 | — | — | US | disclosed |
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183744-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | PDK2, PDK1, PDK3 | PKM 6/4885ALDH1A1 940/4885L3MBTL1 508/4885 |
| US-20130109672-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | PDK2, PDK1, PKLR | PKM 6/4885ALDH1A1 1009/4885L3MBTL1 501/4885 |
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | PKM 4499/4885ALDH1A1 3496/4885L3MBTL1 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.