SCHEMBL10158641

SCHEMBL10158641

CCc1ccc2occc2c1Cl

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.38
HTR2C P28335 6/20 0.38
MAOA P21397 4/20 0.38
MAOB P27338 4/20 0.38
FTO Q9C0B1 1/20 0.38
CTRC Q99895 1/20 0.37
NFKB1 P19838 1/20 0.37
SIGMAR1 Q99720 5/20 0.36
MTNR1A P48039 2/20 0.35
MTNR1B P49286 2/20 0.35
PAX8 Q06710 1/20 0.34
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
DRD4 P21917 1/20 0.33
DRD3 P35462 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL826347 0.82 CTRC (0.42) HTR2AHTR2CMAOAMAOBFTO
SCHEMBL15800545 0.77 GABRA1 (0.43) HTR2AHTR2CMAOAMAOBFTO
SCHEMBL14824860 0.74 HTR2A (0.38) HTR2AHTR2CMAOAMAOBFTO
SCHEMBL8799124 0.73 MAOA (0.40) HTR2AHTR2CMAOAMAOBFTO
SCHEMBL3794946 0.72 MTNR1A (0.51) MAOAMAOBFTOMTNR1AMTNR1B
SCHEMBL20651251 0.72 ALDH1A1 (0.38) MAOAMAOBFTO
SCHEMBL12658946 0.71 CTRC (0.48) HTR2AHTR2CCTRCHTR1ADRD2
SCHEMBL5497618 0.69 CYP3A4 (0.39) HTR2AHTR2CMAOAMAOBFTO
SCHEMBL24946157 0.69 CTRC (0.37) CTRC
SCHEMBL12533388 0.69 MAOA (0.34) HTR2AHTR2CMAOAMAOBFTO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2220046-B1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION GILEAD SCIENCES INC (US) 2014-06-18 EP disclosed
EP-2220095-B1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION GILEAD SCIENCES INC (US) 2013-01-02 EP disclosed
EP-2220076-B1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INT (DE) 2012-01-18 EP disclosed
WO-2009062285-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-05-22 WO disclosed
WO-2009062289-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-05-22 WO disclosed
WO-2009062308-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-05-22 WO disclosed