Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.77 |
| ▸ | NAMPT | P43490 | 3/20 | 0.62 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.60 |
| ▸ | CASR | P41180 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10160169 | 0.86 | HIF1A (0.74) | HIF1ANAMPTCASRRAB9ANPC1 | |
| SCHEMBL306396 | 0.85 | ROCK2 (0.69) | HIF1ANAMPTSENP1MAPTALDH1A1 | |
| SCHEMBL28559306 | 0.85 | NPC1 (0.72) | HIF1ANAMPTRAB9ANPC1HPGD | |
| SCHEMBL2704691 | 0.84 | MAPT (0.66) | HIF1ANAMPTRAB9ANPC1HPGD | |
| SCHEMBL16127714 | 0.83 | KDM4E (0.76) | HIF1ARAB9ANPC1HPGDMAPT | |
| SCHEMBL15761753 | 0.83 | HIF1A (0.85) | HIF1ASENP1RAB9AHPGDALDH1A1 | |
| SCHEMBL13501297 | 0.83 | MMP13 (0.61) | HIF1ARAB9AHPGDMEN1KMT2A | |
| SCHEMBL15600305 | 0.83 | LOXL2 (0.64) | HIF1ASENP1RAB9ANPC1HPGD | |
| SCHEMBL19577671 | 0.80 | NPC1 (0.70) | NAMPTRAB9ANPC1HPGDMAPT | |
| SCHEMBL19634740 | 0.80 | LOXL2 (0.64) | HIF1ANAMPTRAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093266-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-10 | — | — | US | disclosed |
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | HIF1A 2666/4885NAMPT 2698/4885SENP1 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.