Sugi Predict

Sugi Predict / Compounds / SCHEMBL10162424

SCHEMBL10162424

SCHEMBL10162424

CC(=O)c1ccc(CNC(=O)c2cc(C(=O)NCc3cccc(OC(F)F)c3)nc3c(F)cnn23)cc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 4/20 0.47
▸ ADAMTS4 O75173 1/20 0.47
▸ MMP3 P08254 1/20 0.47
▸ TP53 P04637 1/20 0.40
▸ ROCK2 O75116 2/20 0.40
▸ ROCK1 Q13464 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ USP2 O75604 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ KCNA5 P22460 1/20 0.39
▸ KCNH2 Q12809 1/20 0.39
▸ KCNB1 Q14721 1/20 0.39
▸ POLB P06746 2/20 0.39
▸ LMNA P02545 2/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ KLKB1 P03952 1/20 0.38
▸ CLK1 P49759 1/20 0.37
▸ RET P07949 1/20 0.37
▸ RIPK1 Q13546 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10162427 0.92 ADAMTS4 (0.49) MMP13ADAMTS4MMP3ROCK2ROCK1
SCHEMBL10165575 0.89 MMP13 (0.43) MMP13ADAMTS4MMP3TP53ROCK2
SCHEMBL10162402 0.87 MMP13 (0.53) MMP13ADAMTS4MMP3ALDH1A1USP2
SCHEMBL10162431 0.86 MMP13 (0.42) MMP13ADAMTS4MMP3TP53ROCK2
SCHEMBL10162414 0.86 MMP13 (0.52) MMP13ADAMTS4MMP3MAPK1KLKB1
SCHEMBL10162421 0.86 MMP13 (0.50) MMP13ADAMTS4MMP3TP53POLB
SCHEMBL10162411 0.86 MMP13 (0.53) MMP13ADAMTS4MMP3
SCHEMBL8253082 0.85 ADAMTS4 (0.46) MMP13ADAMTS4MMP3TP53ROCK2
SCHEMBL10162395 0.85 ADAMTS4 (0.41) MMP13ADAMTS4MMP3TP53ROCK2
SCHEMBL10162418 0.84 MMP13 (0.50) MMP13ADAMTS4MMP3TP53MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835441-B2 Heterobicyclic metalloprotease inhibitors AMGEN INC. (US) 2014-09-16 — — US disclosed
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2012-01-19 — — US disclosed
US-7795245-B2 Heterobicyclic metalloprotease inhibitors Atlantos Pharmaceuticals Holding, Inc. (US) 2010-09-14 — — US disclosed
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-12-17 — — US disclosed
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. 2009-05-28 — — US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors MMP13, TIMP3, MMP3 MMP13 1/4885ADAMTS4 38/4885MMP3 3/4885
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS MMP13, TIMP3, MMP3 MMP13 1/4885ADAMTS4 38/4885MMP3 3/4885
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 MMP13 1/4885ADAMTS4 38/4885MMP3 3/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 MMP13 1/4885ADAMTS4 38/4885MMP3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.