Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893459 | 0.83 | HRH4 (0.45) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL17462008 | 0.80 | ALDH1A1 (0.52) | KMT2AALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL16014446 | 0.80 | GALR2 (0.46) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL31420881 | 0.78 | CASP1 (0.48) | HRH4KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL10163853 | 0.75 | KMT2A (0.49) | HRH4KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL31421420 | 0.75 | EGLN2 (0.44) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL13111301 | 0.74 | KMT2A (0.55) | HRH4KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL16013236 | 0.72 | NPC1 (0.50) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL893782 | 0.71 | EGLN2 (0.43) | HRH4KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL11485030 | 0.71 | KDM4E (0.48) | KMT2AALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | HRH4 9/4885HRH3 32/4885HTR1A 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.