Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | CASP5 | P51878 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16013236 | 0.89 | NPC1 (0.50) | HRH4HRH3KIF11HTR1AADRA2A | |
| SCHEMBL16013563 | 0.85 | PRKD1 (0.47) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL16014446 | 0.84 | GALR2 (0.46) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL17456777 | 0.83 | PRKD1 (0.41) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL10163852 | 0.83 | HRH4 (0.50) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL16005299 | 0.82 | KIF11 (0.61) | KIF11CTSSCTSK | |
| SCHEMBL893388 | 0.77 | CASP1 (0.50) | HRH4CASP1CASP4CASP5MAPK1 | |
| SCHEMBL28824391 | 0.77 | LMNA (0.46) | KIF11CASP1CASP4CASP5PRKD1 | |
| SCHEMBL3717904 | 0.76 | CASP1 (0.49) | HRH4CASP1CASP4CASP5PRKD1 | |
| SCHEMBL16013728 | 0.75 | KIF11 (0.53) | KIF11CASP1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162844-A1 | CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME | EA PHARMA CO., LTD. (JP) | 2018-06-14 | — | — | US | disclosed |
| EP-3330266-A1 | CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME | EA PHARMA CO., LTD. (JP) | 2018-06-06 | — | — | EP | disclosed |
| US-9409864-B2 | Sulfonamide TRPA1 receptor antagonists | ARIO PHARMA LIMITED (GB) | 2016-08-09 | — | — | US | disclosed |
| US-20160024009-A1 | Novel Sulfonamide TRPA1 Receptor Antagonists | ARIO PHARMA LIMITED (GB) | 2016-01-28 | — | — | US | disclosed |
| EP-2964615-A1 | NOVEL SULFONAMIDE TRPA1 RECEPTOR ANTAGONISTS | Ario Pharma Limited (GB) | 2016-01-13 | — | — | EP | disclosed |
| CN-105143188-A | Novel sulfonamide trpa1 receptor antagonists | PHARMESTE S R L IN LIQUIDATION | 2015-12-09 | — | — | CN | disclosed |
| WO-2014135617-A1 | NOVEL SULFONAMIDE TRPA1 RECEPTOR ANTAGONISTS | PHARMESTE S.R.L. IN LIQUIDATION (IT) | 2014-09-12 | — | — | WO | disclosed |
| EP-2774919-A1 | Novel sulfonamide TRPA1 receptor antagonists | PHARMESTE S.R.L. IN LIQUIDAZIONE (IT) | 2014-09-10 | — | — | EP | disclosed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024009-A1 | Novel Sulfonamide TRPA1 Receptor Antagonists | TRPA1, TRPV1, TRPV2 | HRH4 278/4885HRH3 575/4885KIF11 4145/4885 |
| US-20180162844-A1 | CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME | TRPA1, TRPV1, TRPV2 | HRH4 609/4885HRH3 1407/4885KIF11 4029/4885 |
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | HRH4 9/4885HRH3 32/4885KIF11 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.