Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247694 | 0.89 | MAPK1 (0.37) | MAPK1HPGDGABRG2GABRB3GABRA5 | |
| SCHEMBL8253403 | 0.88 | MAPK1 (0.44) | MAPK1HPGDGABRG2GABRB3GABRA5 | |
| SCHEMBL10164461 | 0.86 | MAPK1 (0.48) | MAPK1HPGDALDH1A1L3MBTL1MEN1 | |
| SCHEMBL10164493 | 0.80 | GABRG2 (0.36) | HPGDGABRG2GABRB3GABRA5ALDH1A1 | |
| SCHEMBL8247048 | 0.77 | MAPK1 (0.50) | MAPK1HPGDALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8253218 | 0.74 | MAPK1 (0.48) | MAPK1HPGDALDH1A1L3MBTL1MEN1 | |
| SCHEMBL10165798 | 0.72 | ALDH1A1 (0.51) | MAPK1HPGDALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8253875 | 0.71 | TRPV1 (0.36) | — | |
| SCHEMBL4264078 | 0.70 | MAPK1 (0.47) | MAPK1HPGDALDH1A1L3MBTL1MEN1 | |
| SCHEMBL4255764 | 0.70 | ALDH1A1 (0.56) | MAPK1HPGDALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835441-B2 | Heterobicyclic metalloprotease inhibitors | AMGEN INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | MAPK1 2860/4885HPGD 313/4885GABRG2 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.