Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164500 | 0.93 | VCP (0.39) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10164538 | 0.92 | ALDH1A1 (0.37) | ALDH1A1PKMLMNANPC1POLB | |
| SCHEMBL893811 | 0.92 | TRPA1 (0.39) | CYP2C9CYP2C19CYP3A4ALDH1A1LMNA | |
| SCHEMBL10164555 | 0.88 | CYP3A4 (0.35) | CYP2C9CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL10164560 | 0.88 | ALDH1A1 (0.42) | CYP2C9CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL10164609 | 0.87 | TRPA1 (0.38) | ALDH1A1LMNATP53POLBTSHR | |
| SCHEMBL10164539 | 0.87 | KDM4E (0.50) | CYP2C9CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL10164549 | 0.86 | TSHR (0.50) | CYP2C9CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL10164581 | 0.85 | CYP2C9 (0.40) | CYP2C9CYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL10164669 | 0.84 | TRPA1 (0.34) | ALDH1A1LMNANPC1TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | CYP2C9 902/4885CYP2C19 1450/4885CYP3A4 1670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.