Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10164515 | 0.94 | TRPA1 (0.42) | L3MBTL1MMP8MMP12MMP13LMNA | |
| SCHEMBL893951 | 0.91 | TRPA1 (0.51) | MMP8MMP12MMP13FKBP1ALMNA | |
| SCHEMBL10164498 | 0.91 | MMP8 (0.46) | L3MBTL1MMP8MMP12MMP13LMNA | |
| SCHEMBL10164583 | 0.90 | TRPA1 (0.44) | L3MBTL1MMP8MMP12MMP13LMNA | |
| SCHEMBL10164507 | 0.89 | L3MBTL1 (0.47) | L3MBTL1MMP8MMP12MMP13FKBP1A | |
| SCHEMBL10164606 | 0.89 | LMNA (0.40) | LMNAMAPK1SMN1; SMN2ALDH1A1TRPA1 | |
| SCHEMBL10164586 | 0.88 | LMNA (0.41) | LMNAMAPK1SMN1; SMN2ALDH1A1TRPA1 | |
| SCHEMBL10164594 | 0.87 | L3MBTL1 (0.53) | L3MBTL1FKBP1ATRPA1CCR4MAPT | |
| SCHEMBL10164505 | 0.86 | L3MBTL1 (0.46) | L3MBTL1MMP8MMP12MMP13FKBP1A | |
| SCHEMBL894094 | 0.86 | TRPA1 (0.51) | MMP8MMP12MMP13ALDH1A1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083474-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | TRPA1, TRPV1, TRPV2 | L3MBTL1 3677/4885MMP8 719/4885MMP12 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.