Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960623 | 0.79 | PTGS2 (0.51) | PTGS2CYP2A6CYP2B6 | |
| SCHEMBL23087491 | 0.74 | TDO2 (0.44) | TDO2ALOX5PTGS2ALDH1A1MAPT | |
| SCHEMBL16702638 | 0.74 | TDO2 (0.59) | TDO2PTGS2ALDH1A1LMNAMAPT | |
| SCHEMBL20033971 | 0.74 | TDO2 (0.40) | TDO2ALOX5PTGS2ALDH1A1LMNA | |
| SCHEMBL10166457 | 0.70 | TDO2 (0.59) | TDO2PTGS2CYP2A6CYP2B6LMNA | |
| SCHEMBL2116877 | 0.69 | LDHA (0.45) | TDO2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL31526110 | 0.69 | TDO2 (0.44) | TDO2ALOX5PTGS2ALDH1A1MAPT | |
| SCHEMBL8283924 | 0.69 | ALDH1A1 (0.42) | TDO2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL10166468 | 0.65 | TDO2 (0.59) | TDO2ALOX5MEN1ALDH1A1LMNA | |
| SCHEMBL16996824 | 0.64 | GRM6 (0.52) | ALOX5MEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824660-A | The method that rhodium catalysis arene oxidizing amination prepares the aromatic amine compounds of 2- pyridyl group substitution | 陕西师范大学 | 2019-05-31 | — | — | CN | disclosed |
| US-8980837-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980837-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-1778718-B1 | INHIBITORS OF IAP | GENENTECH INC (US) | 2014-10-08 | — | — | EP | disclosed |
| US-20120202750-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-8110568-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20110077265-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110077265-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| US-20110046066-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-20100256115-A1 | INHIBITORS OF IAP | COHEN FREDERICK | 2010-10-07 | — | — | US | disclosed |
| WO-2008134679-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299052-A1 | Inhibitors of IAP | XIAP, BIRC5, BIRC3 | TDO2 4611/4885ALOX5 4856/4885PTGS2 4287/4885 |
| US-20110046066-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | TDO2 4711/4885ALOX5 4880/4885PTGS2 3613/4885 |
| US-20120202750-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | TDO2 4611/4885ALOX5 4856/4885PTGS2 4287/4885 |
| US-20100256115-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | TDO2 4611/4885ALOX5 4856/4885PTGS2 4287/4885 |
| US-20110077265-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC2 | TDO2 4768/4885ALOX5 4831/4885PTGS2 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.