Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2458633 | 0.71 | HTR6 (0.58) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL10167015 | 0.71 | RORC (0.38) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL1755239 | 0.71 | ALDH1A1 (0.64) | ALDH1A1POLBMAPTSMN1; SMN2HTR6 | |
| SCHEMBL16481025 | 0.68 | ALDH1A1 (0.51) | ALDH1A1POLBMAPTSMN1; SMN2HTR6 | |
| SCHEMBL4199324 | 0.67 | HTR6 (0.52) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL9805864 | 0.67 | HTR6 (0.52) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL2908734 | 0.67 | HTR6 (0.52) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL11112123 | 0.67 | CA12 (0.61) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL30973847 | 0.67 | HTR6 (0.52) | ALDH1A1POLBMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL10975673 | 0.67 | TSHR (0.58) | ALDH1A1POLBMAPTHTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8692001-B2 | Sulfonamides for the modulation of PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2014-04-08 | — | — | US | disclosed |
| US-8692001-B2 | Sulfonamides for the modulation of PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2014-04-08 | — | — | US | disclosed |
| WO-2012056319-A1 | SULFONAMIDES FOR THE MODULATION OF PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-05-03 | — | — | WO | disclosed |
| US-20120108631-A1 | Sulfonamides for the Modulation of PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-05-03 | — | — | US | disclosed |
| US-20120108631-A1 | Sulfonamides for the Modulation of PKM2 | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108631-A1 | Sulfonamides for the Modulation of PKM2 | PDK1, PDK4, PDK2 | NR1H3 2862/4885ALDH1A1 2275/4885POLB 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.