Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.80 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.80 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176164 | 0.89 | CYP11B2 (1.00) | CYP11B2CYP11B1ATMKITUSP2 | |
| SCHEMBL10176202 | 0.84 | CYP11B2 (0.73) | CYP11B2CYP11B1ATMNAMPTKIT | |
| SCHEMBL10176218 | 0.83 | CYP11B2 (0.60) | CYP11B2CYP11B1ATMNAMPTALOX5AP | |
| SCHEMBL10175606 | 0.83 | CYP11B2 (0.60) | CYP11B2CYP11B1ATMNAMPTALOX5AP | |
| SCHEMBL17896718 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1ATMHTR2B | |
| SCHEMBL17896626 | 0.83 | HTR2B (0.67) | CYP11B2CYP11B1ATMNAMPTALOX5AP | |
| SCHEMBL10175594 | 0.83 | CYP11B2 (0.81) | CYP11B2CYP11B1ALOX5APHTR2BHTR6 | |
| SCHEMBL17896717 | 0.82 | MEN1 (0.62) | CYP11B2CYP11B1ATMNAMPTALOX5AP | |
| SCHEMBL10175817 | 0.81 | RAD51 (0.60) | CYP11B2CYP11B1ATMNAMPTKIT | |
| SCHEMBL1104859 | 0.81 | MEN1 (0.69) | CYP11B2CYP11B1ATMUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |