Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17897060 | 0.89 | MEN1 (0.57) | MEN1KMT2ACYP11B2ATMPKN1 | |
| SCHEMBL13749911 | 0.87 | ATM (0.52) | MEN1KMT2ACYP11B2ATMCA12 | |
| SCHEMBL4243953 | 0.84 | CYP11B2 (0.69) | CYP11B2ATMCYP11B1NAMPT | |
| SCHEMBL10175348 | 0.82 | CYP11B2 (0.48) | MEN1KMT2ACYP11B2ATMCA12 | |
| SCHEMBL10249140 | 0.80 | MEN1 (0.66) | MEN1KMT2AATMCA12CA1 | |
| SCHEMBL17896641 | 0.80 | CYP11B2 (0.47) | CYP11B2ATMKDM4EALDH1A1GAA | |
| SCHEMBL10175342 | 0.80 | CYP11B2 (0.46) | CYP11B2ATMCA12CA1CA2 | |
| SCHEMBL12217711 | 0.79 | KDM4E (0.56) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL10953589 | 0.79 | KDM4E (0.50) | MEN1KMT2ACYP11B2KDM4EALDH1A1 | |
| SCHEMBL17896642 | 0.78 | ALOX5AP (0.46) | CYP11B2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |