Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.81 |
| ▸ | NPC1 | O15118 | 9/20 | 0.81 |
| ▸ | RAB9A | P51151 | 9/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.81 |
| ▸ | HPGD | P15428 | 7/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.81 |
| ▸ | HTT | P42858 | 3/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 8/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214873 | 0.88 | TP53 (0.79) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2496169 | 0.87 | TP53 (0.77) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10360610 | 0.85 | NPC1 (0.73) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10226093 | 0.85 | TP53 (0.73) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10226088 | 0.75 | LMNA (0.66) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19700808 | 0.74 | KDM4E (0.62) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8344591 | 0.71 | LMNA (0.74) | TP53NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL10360896 | 0.71 | NPC1 (0.42) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6206370 | 0.68 | KDM4E (0.73) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24392129 | 0.68 | NPC1 (0.66) | TP53NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |