Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.31 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176343 | 0.74 | ALDH1A1 (0.43) | TSHRALDH1A1HAO1PLA2G10IL1R1 | |
| SCHEMBL10176491 | 0.67 | TSHR (0.42) | TSHRALDH1A1MAPK1MEN1MAPT | |
| SCHEMBL17718408 | 0.67 | ALDH1A1 (0.53) | TSHRALDH1A1HAO1PLA2G10MAPK1 | |
| SCHEMBL13425011 | 0.67 | ALDH1A1 (0.45) | TSHRALDH1A1PLA2G10MAPK1HSD17B10 | |
| SCHEMBL12534057 | 0.66 | ALDH1A1 (0.47) | TSHRALDH1A1HAO1PLA2G10MAPK1 | |
| SCHEMBL22008359 | 0.65 | PRKCI (0.49) | TSHR | |
| SCHEMBL11377189 | 0.64 | ALDH1A1 (0.49) | TSHRALDH1A1PLA2G10MAPK1CYP19A1 | |
| SCHEMBL28236106 | 0.62 | TSHR (0.54) | TSHRALDH1A1HAO1PLA2G10CYP19A1 | |
| SCHEMBL12260369 | 0.62 | ALDH1A1 (0.43) | TSHRALDH1A1HAO1PLA2G10CYP19A1 | |
| SCHEMBL25038685 | 0.61 | L3MBTL1 (0.50) | ALDH1A1IL1R1MEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | TSHR 4545/4885ALDH1A1 1001/4885HAO1 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.