Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14845707 | 0.87 | ALDH1A1 (0.52) | ALDH1A1HRH3CES2CES1TP53 | |
| SCHEMBL15417860 | 0.85 | HRH3 (0.56) | ALDH1A1HRH3CES2CES1KMT2A | |
| SCHEMBL15726601 | 0.84 | HRH3 (0.58) | ALDH1A1HRH3CES2CES1KMT2A | |
| SCHEMBL8206737 | 0.84 | HRH3 (0.58) | ALDH1A1HRH3CES2CES1KMT2A | |
| SCHEMBL619220 | 0.82 | ALDH1A1 (0.55) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7624172 | 0.81 | KMT2A (0.37) | ALDH1A1HRH3TP53FFAR3KMT2A | |
| SCHEMBL1104286 | 0.80 | PHF8 (0.45) | HDAC3HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL11522117 | 0.80 | ALDH1A1 (0.44) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12016626 | 0.79 | HRH3 (0.58) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10170 | 0.78 | HDAC2 (0.52) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180126011-A1 | DENDRI-TAC AND THEIR USE AS THERANOSTICS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-05-10 | — | — | US | disclosed |
| US-8637557-B2 | Aminothiazole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-01-28 | — | — | US | disclosed |
| US-20120220767-A1 | AMINOTHIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-08-30 | — | — | US | disclosed |
| WO-2011048936-A1 | AMINOTHIAZOLE DERIVATIVE | 大正製薬株式会社 (JP) | 2011-04-28 | — | — | WO | disclosed |
| EP-0521997-A4 | CROSSLINKABLE SURFACE COATINGS AND METHODS FOR PRODUCING SAME | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0521997-A1 | CROSSLINKABLE SURFACE COATINGS AND METHODS FOR PRODUCING SAME. | JOHNSON & SON INC S C (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014715-A1 | CROSSLINKABLE SURFACE COATINGS AND METHODS FOR PRODUCING SAME | S.C. JOHNSON & SON, INC. (US) | 1991-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220767-A1 | AMINOTHIAZOLE DERIVATIVE | AKT3, AKT2, JAK1 | HDAC3 2032/4885HDAC1 2146/4885HDAC2 2157/4885 |
| US-20180126011-A1 | DENDRI-TAC AND THEIR USE AS THERANOSTICS | DBI, CDIPT, DGKI | HDAC3 2460/4885HDAC1 3687/4885HDAC2 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.