Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | CES1 | P23141 | 4/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206737 | 0.98 | HRH3 (0.58) | HRH3ALDH1A1HSP90AA1FAAHMEN1 | |
| SCHEMBL15726601 | 0.98 | HRH3 (0.58) | HRH3ALDH1A1HSP90AA1FAAHMEN1 | |
| SCHEMBL14845707 | 0.94 | ALDH1A1 (0.52) | HRH3ALDH1A1HSP90AA1FAAHMEN1 | |
| SCHEMBL10179 | 0.85 | HDAC3 (0.46) | HRH3ALDH1A1MEN1KMT2ACES2 | |
| SCHEMBL15726667 | 0.84 | DGKA (0.56) | HRH3FAAHMEN1KMT2ADNM1 | |
| SCHEMBL12328992 | 0.84 | ALDH1A1 (0.46) | HRH3ALDH1A1MEN1KMT2AAKR1B1 | |
| SCHEMBL11522117 | 0.83 | ALDH1A1 (0.44) | HRH3ALDH1A1KMT2A | |
| SCHEMBL23392423 | 0.82 | ALDH1A1 (0.63) | HRH3ALDH1A1HSP90AA1FAAHMEN1 | |
| SCHEMBL10689611 | 0.82 | ALDH1A1 (0.63) | HRH3ALDH1A1HSP90AA1FAAHMEN1 | |
| SCHEMBL11922964 | 0.82 | ALDH1A1 (0.63) | HRH3ALDH1A1HSP90AA1FAAHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-05-02 | — | — | US | disclosed |
| US-10975061-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200115366-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2020-04-16 | — | — | US | disclosed |
| US-20160332997-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2016-11-17 | — | — | US | disclosed |
| US-20160271105-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2016-09-22 | — | — | US | disclosed |
| US-20150231142-A1 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | VERTEX PHARMA (US) | 2015-08-20 | — | — | US | disclosed |
| US-20140329814-A2 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | VERTEX PHARMA (US) | 2014-11-06 | — | — | US | disclosed |
| US-8623905-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329814-A2 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | CFTR, SLC26A4, ABCB11 | HRH3 3800/4885ALDH1A1 2535/4885HSP90AA1 2761/4885 |
| US-10975061-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | HRH3 3382/4885ALDH1A1 1961/4885HSP90AA1 1161/4885 |
| US-20160332997-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HRH3 3382/4885ALDH1A1 1961/4885HSP90AA1 1161/4885 |
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | HRH3 3382/4885ALDH1A1 1961/4885HSP90AA1 1161/4885 |
| US-20200115366-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HRH3 3382/4885ALDH1A1 1961/4885HSP90AA1 1161/4885 |
| US-20150231142-A1 | Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases | CFTR, SLC26A4, ABCB11 | HRH3 3800/4885ALDH1A1 2535/4885HSP90AA1 2761/4885 |
| US-20160271105-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | HRH3 3382/4885ALDH1A1 1961/4885HSP90AA1 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.