SCHEMBL10179669

SCHEMBL10179669

O=C(O)N1CCC(c2ccc(Cn3ccc4cc(-n5cnnn5)cc(F)c43)nc2)CC1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KCNJ1 P48048 9/20 0.38
KCNH2 Q12809 6/20 0.36
GPR119 Q8TDV5 5/20 0.36
SSTR2 P30874 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
F11 P03951 4/20 0.34
KLKB1 P03952 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14141945 0.91 ALDH1A1 (0.36) KCNJ1KCNH2GPR119ALDH1A1HPGD
SCHEMBL10179902 0.90 ALDH1A1 (0.36) KCNJ1KCNH2GPR119SSTR2ALDH1A1
SCHEMBL10179177 0.89 EGLN1 (0.34) KCNJ1KCNH2GPR119ALDH1A1HPGD
SCHEMBL14141977 0.89 KCNJ1 (0.36) KCNJ1KCNH2GPR119SSTR2ALDH1A1
SCHEMBL10179766 0.89 GPR119 (0.49) KCNH2GPR119F11
SCHEMBL12544773 0.89 GPR119 (0.39) KCNJ1KCNH2GPR119SSTR2ALDH1A1
SCHEMBL10181205 0.86 ALDH1A1 (0.38) KCNJ1KCNH2GPR119ALDH1A1HPGD
SCHEMBL10187772 0.85 P2RY14 (0.33) KCNJ1KCNH2GPR119F11
SCHEMBL10179406 0.84 EGLN1 (0.35) KCNH2
SCHEMBL10179456 0.81 PRMT5 (0.38) KCNJ1KCNH2GPR119ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120245344-A1 GPR119 AGONIST NIPPON CHEMIPHAR CO., LTD. (JP) 2012-09-27 US disclosed
EP-2474540-A1 GPR119 AGONIST Nippon Chemiphar Co., Ltd. (JP) 2012-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120245344-A1 GPR119 AGONIST GPR119, GPR4, GPR55 KCNJ1 789/4885KCNH2 484/4885GPR119 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.