SCHEMBL10180753

SCHEMBL10180753

C=CC(=O)Oc1cc(F)ccc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
THRB P10828 3/20 0.40
THRA P10827 1/20 0.40
CYP4F2 P78329 1/20 0.39
CYP4A11 Q02928 1/20 0.39
POLB P06746 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
TGM2 P21980 1/20 0.37
CA3 P07451 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
EGFR P00533 1/20 0.35
TYMS P04818 1/20 0.35
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7417795 0.86 TSHR (0.49) CES2CES1THRBTHRAPOLB
SCHEMBL30310524 0.84 GAA (0.42) THRBTHRACYP4F2CYP4A11TSHR
SCHEMBL20533784 0.83 KEAP1 (0.43) CES2CES1THRBTHRAPOLB
SCHEMBL28750112 0.83 FFAR1 (0.43) CES2CES1THRBTHRAPOLB
SCHEMBL30596839 0.81 THRB (0.49) CES2CES1THRBTHRATYMS
SCHEMBL2933377 0.81 THRB (0.49) CES2CES1THRBTHRATYMS
SCHEMBL4269240 0.80 ALDH1A1 (0.44) THRBTGM2MEN1MAPTKMT2A
SCHEMBL11251813 0.80 FFAR4 (0.39) THRBTHRAPOLBTSHRMAPK1
Hydrochloric Acid SCHEMBL28527576 0.80 THRB (0.48) CES2CES1THRBTHRATYMS
SCHEMBL10180914 0.79 THRB (0.36) THRBTHRACYP4F2CYP4A11POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104112870-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2014-10-22 CN disclosed
US-20130244122-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME ONUKI MASAMICHI (JP) 2013-09-19 US disclosed
US-20120219866-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2012-08-30 US disclosed
EP-2475041-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION, AND NON-AQUEOUS ELECTROLYTE BATTERY COMPRISING SAME Mitsubishi Chemical Corporation (JP) 2012-07-11 EP disclosed
CN-102484281-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2012-05-30 CN disclosed
CN-100562516-C Amyloid-beta produces and the excretory inhibitor DAIICHI SEIYAKU CO (JP) 2009-11-25 CN disclosed
CN-101400674-A Antibiotic compounds ACTELION PHARMACEUTICALS LTD (CH) 2009-04-01 CN disclosed
CN-101384604-A Ethanol or ethylene glycol cyclohexyl antibiotic derivatives ACTELION PHARMACEUTICALS LTD (CH) 2009-03-11 CN disclosed
CN-101374831-A tetrahydropyran antibiotics ACTELION PHARMACEUTICALS LTD (CH) 2009-02-25 CN disclosed
CN-1585746-A Inhibitors of beta-amyloid production and secretion DAIICHI SEIYAKU CO (JP) 2005-02-23 CN disclosed