SCHEMBL7417795

SCHEMBL7417795

C=CC(=O)Oc1ccc(F)cc1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.49
POLB P06746 1/20 0.49
MAPK1 P28482 1/20 0.49
L3MBTL1 Q9Y468 2/20 0.41
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.41
CES2 O00748 2/20 0.41
CES1 P23141 2/20 0.41
THRB P10828 2/20 0.40
THRA P10827 1/20 0.40
KDM4E B2RXH2 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
FAAH O00519 2/20 0.39
TYMS P04818 1/20 0.38
HSPB1 P04792 1/20 0.37
TGM2 P21980 1/20 0.37
BRD4 O60885 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10180753 0.86 CES2 (0.41) TSHRPOLBMAPK1MEN1MAPT
SCHEMBL10314652 0.86 THRB (0.44) TSHRPOLBMAPK1MEN1MAPT
SCHEMBL9607776 0.86 ERN1 (0.40) TSHRPOLBMAPK1THRBTHRA
SCHEMBL20342995 0.83 ESR2 (0.42) TSHRPOLBMAPK1TYMS
SCHEMBL8899213 0.83 MAPT (0.42) TSHRPOLBMAPK1L3MBTL1MEN1
SCHEMBL39799 0.83 MRGPRX4 (0.42) TSHRPOLBMAPK1L3MBTL1KMT2A
SCHEMBL29259274 0.83 PPARG (0.47) TSHRKMT2ATYMS
SCHEMBL27850463 0.83 DGAT1 (0.42) TSHRPOLBMAPK1L3MBTL1MAPT
SCHEMBL2604656 0.82 ERN1 (0.39) TSHRPOLBMAPK1MAPTTHRB
SCHEMBL2933377 0.81 THRB (0.49) L3MBTL1MAPTHPGDKMT2ACES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116768792-A Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof 浙江工业大学 2023-09-19 CN disclosed
CN-104112870-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2014-10-22 CN disclosed
US-20130244122-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME ONUKI MASAMICHI (JP) 2013-09-19 US disclosed
US-20120219866-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2012-08-30 US disclosed
EP-2475041-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION, AND NON-AQUEOUS ELECTROLYTE BATTERY COMPRISING SAME Mitsubishi Chemical Corporation (JP) 2012-07-11 EP disclosed
CN-102484281-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2012-05-30 CN disclosed
US-4631283-A RENAL VASODILATORS, CARDIOVASCULAR AGENTS ORTHO PHARMACEUTICAL CORPORATION (US) 1986-12-23 US disclosed
EP-0107398-A1 Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids ORTHO PHARMACEUTICAL CORPORATION (US) 1984-05-02 EP disclosed