SCHEMBL10183373

SCHEMBL10183373

OC[C@H]1O[C@@H](c2ccc(-c3ccccn3)nc2)CC1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SLC5A2 P31639 2/20 0.36
P4HTM Q9NXG6 2/20 0.35
KDM4E B2RXH2 3/20 0.35
LMNA P02545 3/20 0.35
CCR1 P32246 2/20 0.35
CCR5 P51681 2/20 0.35
CCR8 P51685 2/20 0.35
POLB P06746 1/20 0.35
METAP1 P53582 1/20 0.35
BLM P54132 1/20 0.35
HIF1A Q16665 1/20 0.35
DOHH Q9BU89 1/20 0.35
L3MBTL1 Q9Y468 3/20 0.35
TP53 P04637 2/20 0.35
ALOX15 P16050 2/20 0.35
HTT P42858 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13705702 1.00 CYP1A2 (0.38) CYP1A2CYP2C9CYP2C19SLC5A2P4HTM
SCHEMBL19135074 1.00 CYP1A2 (0.38) CYP1A2CYP2C9CYP2C19SLC5A2P4HTM
SCHEMBL14533667 0.79 PIM1 (0.35) SLC5A2LMNAHIF1ATP53HTT
SCHEMBL14507291 0.79 PIM1 (0.35) SLC5A2LMNAHIF1ATP53HTT
SCHEMBL15129319 0.78 DRD2 (0.41) SLC5A2LMNATP53HTTSMN1; SMN2
SCHEMBL14391672 0.78 DRD2 (0.41) SLC5A2LMNATP53HTTSMN1; SMN2
SCHEMBL10183381 0.78 DRD2 (0.41) SLC5A2LMNATP53HTTSMN1; SMN2
SCHEMBL19135285 0.78 DRD2 (0.41) SLC5A2LMNATP53HTTSMN1; SMN2
SCHEMBL14533671 0.76 CYP2A6 (0.58) POLBSMN1; SMN2CYP2A6
SCHEMBL5878277 0.76 CYP2A6 (0.58) POLBSMN1; SMN2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220403377-A1 MODIFIED iRNA AGENTS ALNYLAM PHARMACEUTICALS, INC. 2022-12-22 US disclosed
US-11530408-B2 Therapeutic compositions ALNYLAM PHARMACEUTICALS, INC. (US) 2022-12-20 US disclosed
US-11312957-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2022-04-26 US disclosed
US-20200255833-A1 THERAPEUTIC COMPOSITIONS BANK OF AMERICA, N.A. 2020-08-13 US disclosed
US-10676740-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2020-06-09 US disclosed
US-10669544-B2 Therapeutic compositions ALNYLAM PHARMACEUTICALS, INC. (US) 2020-06-02 US disclosed
US-20190345498-A1 MODIFIED iRNA AGENTS BANK OF AMERICA, N.A. 2019-11-14 US disclosed
US-20190264207-A1 THERAPEUTIC COMPOSITIONS BANK OF AMERICA, N.A. 2019-08-29 US disclosed
US-10273477-B2 Therapeutic compositions ALNYLAM PHARMACEUTICALS, INC. (US) 2019-04-30 US disclosed
US-20170283801-A1 THERAPEUTIC COMPOSITIONS BANK OF AMERICA, N.A. 2017-10-05 US disclosed
US-20110054160-A1 THERAPEUTIC COMPOSITIONS ALNYLAM PHARMACEUTICALS (US) 2011-03-03 US disclosed
US-20100292455-A1 MODIFIED iRNA AGENTS ALNYLAM PHARMACEUTICALS (US) 2010-11-18 US disclosed
US-20100292455-A1 MODIFIED iRNA AGENTS ALNYLAM PHARMACEUTICALS (US) 2010-11-18 US disclosed
US-20100240881-A1 THERAPEUTIC COMPOSITIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-09-23 US disclosed
US-20100240881-A1 THERAPEUTIC COMPOSITIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2010-09-23 US disclosed
EP-1605978-B1 THERAPEUTIC COMPOSITIONS ALNYLAM PHARMACEUTICALS INC (US) 2010-09-01 EP disclosed
US-7745608-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2010-06-29 US disclosed
US-7745608-B2 Modified iRNA agents ALNYLAM PHARMACEUTICALS, INC. (US) 2010-06-29 US disclosed
US-20070275914-A1 Therapeutic Compositions BANK OF AMERICA, N.A. 2007-11-29 US disclosed
US-20070179100-A1 Protected monomers ALNYLAM PHARMACEUTICALS, INC. 2007-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10273477-B2 Therapeutic compositions SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-20220403377-A1 MODIFIED iRNA AGENTS NCL, HNRNPA0, HNRNPA1 CYP1A2 3847/4885CYP2C9 4443/4885CYP2C19 4752/4885
US-20110054160-A1 THERAPEUTIC COMPOSITIONS SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-20190345498-A1 MODIFIED iRNA AGENTS NCL, HNRNPA0, HNRNPA1 CYP1A2 3847/4885CYP2C9 4443/4885CYP2C19 4752/4885
US-20100292455-A1 MODIFIED iRNA AGENTS NCL, HNRNPA0, HNRNPA1 CYP1A2 3847/4885CYP2C9 4443/4885CYP2C19 4752/4885
US-20190264207-A1 THERAPEUTIC COMPOSITIONS SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-20200255833-A1 THERAPEUTIC COMPOSITIONS SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-20070275914-A1 Therapeutic Compositions AGO2, EXOSC5, RNASE1 CYP1A2 4371/4885CYP2C9 4650/4885CYP2C19 4431/4885
US-20100240881-A1 THERAPEUTIC COMPOSITIONS SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-10676740-B2 Modified iRNA agents NCL, HNRNPA0, HNRNPA1 CYP1A2 3847/4885CYP2C9 4443/4885CYP2C19 4752/4885
US-11530408-B2 Therapeutic compositions SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-20170283801-A1 THERAPEUTIC COMPOSITIONS SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-10669544-B2 Therapeutic compositions SNRPE, HNRNPH3, RNASE1 CYP1A2 4881/4885CYP2C9 4884/4885CYP2C19 4882/4885
US-11312957-B2 Modified iRNA agents NCL, HNRNPA0, HNRNPA1 CYP1A2 3847/4885CYP2C9 4443/4885CYP2C19 4752/4885
US-20070179100-A1 Protected monomers PCNA, POLN, PARP1 CYP1A2 2684/4885CYP2C9 3809/4885CYP2C19 4218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.