Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185235 | 0.91 | NR1H4 (0.43) | NPC1RAB9ADGAT1 | |
| SCHEMBL10186453 | 0.91 | DGAT1 (0.42) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10185012 | 0.91 | NPC1 (0.49) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10184935 | 0.90 | TAS1R3 (0.44) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10184390 | 0.90 | NPC1 (0.48) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10185397 | 0.90 | NPC1 (0.48) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10186424 | 0.90 | ALDH1A1 (0.46) | NPC1DGAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10185018 | 0.89 | RAB9A (0.59) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10185016 | 0.89 | RAB9A (0.59) | NPC1RAB9ADGAT1SMN1; SMN2MAPT | |
| SCHEMBL10184366 | 0.89 | PDE4A (0.41) | DGAT1SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | NPC1 201/4885RAB9A 1660/4885DGAT1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.