Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183302 | 0.79 | PTAFR (0.41) | LMNAPTAFRALDH1A1PKMHTT | |
| SCHEMBL10184165 | 0.78 | IDH1 (0.52) | LMNAPTAFRALDH1A1PKMHTT | |
| SCHEMBL10183233 | 0.78 | CHRM2 (0.44) | ALDH1A1USP2TSHRMAPTOPRM1 | |
| SCHEMBL10183828 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TRPM8SMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL10183826 | 0.73 | SMN1; SMN2 (0.43) | ALDH1A1TRPM8SMN1; SMN2MAPTOPRM1 | |
| SCHEMBL10183207 | 0.72 | TSHR (0.42) | LMNAALDH1A1HTTUSP2TSHR | |
| SCHEMBL10183670 | 0.71 | TRPM8 (0.41) | TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10184045 | 0.71 | OPRM1 (0.42) | ALDH1A1TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10185945 | 0.70 | OPRM1 (0.39) | ADAM17ALDH1A1TRPM8OPRM1OPRK1 | |
| SCHEMBL15118959 | 0.69 | IDH1 (0.63) | LMNAALDH1A1HTTIDH1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |