Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183233 | 0.77 | CHRM2 (0.44) | ALDH1A1CHRM2CHRM1CHRM3OPRM1 | |
| SCHEMBL10183826 | 0.75 | SMN1; SMN2 (0.43) | ALDH1A1TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10185542 | 0.75 | LMNA (0.39) | ALDH1A1TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10183902 | 0.74 | OPRM1 (0.39) | ALDH1A1TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10184045 | 0.73 | OPRM1 (0.42) | ALDH1A1TRPM8CHRM2CHRM1CHRM3 | |
| SCHEMBL10183809 | 0.73 | CCKBR (0.41) | ALDH1A1CCKBROPRM1OPRK1OPRL1 | |
| SCHEMBL10183649 | 0.72 | OPRM1 (0.38) | ALDH1A1CHRM2CHRM1CHRM3OPRM1 | |
| SCHEMBL10183656 | 0.71 | SIGMAR1 (0.39) | ALDH1A1TRPM8OPRM1OPRK1OPRL1 | |
| SCHEMBL10185945 | 0.71 | OPRM1 (0.39) | ALDH1A1TRPM8CCKBRCHRM2CHRM1 | |
| SCHEMBL10185926 | 0.71 | OPRM1 (0.39) | ALDH1A1OPRM1OPRK1OPRL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |