Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664247 | 0.86 | REN (0.42) | MEN1KMT2AALDH1A1ALOX15ADRA2A | |
| SCHEMBL9179529 | 0.80 | MEN1 (0.53) | MEN1KMT2AKDM4EPARP1CYP1A2 | |
| SCHEMBL8230602 | 0.79 | HTR3E (0.48) | MEN1KMT2AKDM4ECYP1A2TSHR | |
| SCHEMBL8673292 | 0.79 | KDM4E (0.55) | MEN1KMT2AKDM4EPARP1CYP1A2 | |
| SCHEMBL89562 | 0.76 | HTR3E (0.51) | MEN1KMT2AKDM4ECYP1A2TSHR | |
| SCHEMBL10186690 | 0.74 | ALDH1A1 (0.36) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8671753 | 0.73 | CYP1A2 (0.53) | MEN1KMT2AKDM4EPARP1CYP1A2 | |
| SCHEMBL7852029 | 0.72 | MEN1 (0.51) | MEN1KMT2AKDM4EPARP1CYP1A2 | |
| SCHEMBL8673322 | 0.72 | KDM4E (0.54) | MEN1KMT2AKDM4EPARP1CYP1A2 | |
| SCHEMBL8671748 | 0.72 | MEN1 (0.51) | MEN1KMT2AKDM4EPARP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MEN1 3395/4885KMT2A 4587/4885KDM4E 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.