Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.55 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | FASN | P49327 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901002 | 0.85 | DGAT1 (0.74) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL901150 | 0.80 | DGAT1 (0.53) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL902158 | 0.77 | DGAT1 (0.50) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL902547 | 0.75 | DGAT1 (0.78) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10188914 | 0.73 | DGAT1 (0.69) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902462 | 0.72 | DGAT1 (0.73) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902705 | 0.71 | DGAT1 (0.55) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10189666 | 0.70 | DGAT1 (0.56) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10189104 | 0.70 | DGAT1 (0.52) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL14971589 | 0.70 | DGAT1 (0.65) | DGAT1SOAT1KCNH2ADORA2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |