Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.61 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.61 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.61 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.61 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.61 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090612 | 0.80 | HRH3 (0.82) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL11899308 | 0.80 | RAB9A (0.83) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL1374209 | 0.80 | HRH3 (1.00) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL27914448 | 0.79 | HRH3 (0.76) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL14724514 | 0.79 | HRH3 (0.71) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL3141155 | 0.78 | HRH3 (0.73) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL14714478 | 0.77 | HRH3 (0.77) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL14714916 | 0.76 | HRH3 (1.00) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| SCHEMBL27896953 | 0.76 | HRH3 (0.76) | HRH3HRH2HRH1MAPK1ALDH1A1 | |
| Pramoxine SCHEMBL26020 | 0.75 | ALDH1A1 (1.00) | HRH3HRH2HRH1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207168-B2 | Pyridazinone derivatives | CEPHALON, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-8207168-B2 | Pyridazinone derivatives | CEPHALON, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100280007-A1 | Pyridazinone Derivatives | CEPHALON, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280007-A1 | Pyridazinone Derivatives | CEPHALON, INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280007-A1 | Pyridazinone Derivatives | HRH3, HNMT, HRH4 | HRH3 1/4885HRH2 7/4885HRH1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.