Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178167 | 0.85 | RAF1 (0.64) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL1506401 | 0.83 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL13852622 | 0.83 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL10199945 | 0.77 | RAF1 (0.76) | MEN1KMT2AGSK3BMAPK1RAF1 | |
| SCHEMBL12636179 | 0.75 | L3MBTL1 (0.51) | MEN1KMT2ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL7574156 | 0.73 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL12719565 | 0.72 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL30949305 | 0.72 | MEN1 (0.79) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL30949321 | 0.70 | MEN1 (0.59) | MEN1KMT2ASMN1; SMN2L3MBTL1HPGD | |
| SCHEMBL1506347 | 0.69 | MAPT (0.52) | MEN1KMT2AMAPTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153823-A1 | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors | BAYER HEALTHCARE LLC | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153823-A1 | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors | BRAF, RAF1, ARAF | MEN1 4567/4885KMT2A 1777/4885SMN1; SMN2 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.