Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178167 | 0.79 | RAF1 (0.64) | MEN1KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL8103149 | 0.76 | MEN1 (0.67) | MEN1KMT2ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL30949321 | 0.76 | MEN1 (0.59) | MEN1KMT2AGSK3BHPGDTSHR | |
| SCHEMBL7574161 | 0.75 | GSK3B (0.59) | MEN1KMT2AGSK3BHPGDTSHR | |
| SCHEMBL30949348 | 0.75 | GSK3B (0.67) | MEN1KMT2AGSK3BHPGDTSHR | |
| SCHEMBL12719565 | 0.74 | MEN1 (0.54) | MEN1KMT2AGSK3BHPGDTSHR | |
| SCHEMBL16628070 | 0.73 | RAF1 (0.73) | MEN1KMT2AGSK3BMAOAKDR | |
| SCHEMBL1506401 | 0.73 | MEN1 (0.56) | MEN1KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL30949334 | 0.73 | MAPT (0.83) | MEN1KMT2AGSK3BHPGDTSHR | |
| SCHEMBL7759976 | 0.73 | MEN1 (0.68) | MEN1KMT2ATSHRSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002062763-A2 | INHIBITION OF RAF KINASE USING QUINOLYL ISOQUINOLYL OR PYRIDYL UREAS | BAYER CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |