Sugi Predict

Sugi Predict / Compounds / SCHEMBL10214972

SCHEMBL10214972

SCHEMBL10214972

CN(C)Cc1cc2cc(-c3cnc(N)c(OCc4ccccc4)c3)ccc2[nH]1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ LOXL2 Q9Y4K0 3/20 0.55
▸ MAP4K4 O95819 1/20 0.51
▸ MAP4K3 Q8IVH8 1/20 0.43
▸ MAOA P21397 1/20 0.41
▸ MAOB P27338 1/20 0.41
▸ PRMT5 O14744 1/20 0.39
▸ MET P08581 2/20 0.39
▸ LTA4H P09960 1/20 0.38
▸ MAPK14 Q16539 1/20 0.38
▸ ALOX5AP P20292 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10214979 0.78 MAP4K4 (0.58) LOXL2MAP4K4MAP4K3ALOX5AP
SCHEMBL27650107 0.74 MET (0.60) LOXL2MAP4K4MAP4K3MET
SCHEMBL488178 0.74 MAP4K4 (0.75) MAP4K4MAP4K3MAOBMETLTA4H
SCHEMBL487854 0.72 MAP4K4 (0.76) MAP4K4MAP4K3METLTA4HMAPK14
SCHEMBL30452754 0.72 MAP4K4 (0.76) MAP4K4MAP4K3METLTA4HMAPK14
SCHEMBL30453947 0.72 MAP4K4 (0.68) MAP4K4MAP4K3METLTA4HMAPK14
SCHEMBL487917 0.72 MAP4K4 (0.68) MAP4K4MAP4K3METLTA4HMAPK14
SCHEMBL27650273 0.71 MET (0.59) LOXL2MAP4K4MAP4K3MET
SCHEMBL19964313 0.71 LOXL2 (1.00) LOXL2MAOAMAOB
Hydrochloric Acid SCHEMBL19953384 0.70 LOXL2 (0.98) LOXL2MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140288086-A1 ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS PFIZER INC. (US) 2014-09-25 — — US disclosed
US-8785632-B2 Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors AGOURON PHARMACEUTICALS, INC. (US) 2014-07-22 — — US disclosed
US-20120263706-A1 ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS AGOURON PHARMACEUTICALS, INC. 2012-10-18 — — US disclosed
US-8106197-B2 Aminoheteroaryl compounds as protein kinase inhibitors PFIZER INC. (US) 2012-01-31 — — US disclosed
US-7230098-B2 2-amino- pyridines and pyrazines additionally substituted witn one or more carbocyclic or heterocyclic groups, e.g., 4-[6-amino-5-(2,6-dichloro-benzyloxy)-pyridin-3-yl]-phenol, for treating many kinds of cancer SUGEN, INC. (US) 2007-06-12 — — US disclosed
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors SUGEN, INC. 2007-03-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120263706-A1 ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS MET, MAP3K15, MAP3K1 LOXL2 1732/4885MAP4K4 28/4885MAP4K3 24/4885
US-20070072874-A1 Aminoheteroaryl compounds as protein kinase inhibitors MET, MAP4K1, MAP4K2 LOXL2 2657/4885MAP4K4 10/4885MAP4K3 8/4885
US-20140288086-A1 ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS MET, MAP3K15, MAP3K1 LOXL2 1732/4885MAP4K4 28/4885MAP4K3 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.