Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL125010 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL6712839 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL8090124 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL10724821 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL5702427 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL64468 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL3151431 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL6712907 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL1022858 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB | |
| SCHEMBL3146039 | 0.94 | EPHX1 (0.37) | EPHX1HPGDEPHX2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 464 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12370129-B2 | Storage-stable dental adhesive set for use with peroxidically and hydroperoxidically redox-initiated composites | IVOCLAR VIVADENT AG (LI) | 2025-07-29 | — | — | US | claimed |
| CN-119143639-A | Synthesis method of methane bis (benzenesulfonate) | 苏州华道生物药业股份有限公司 | 2024-12-17 | — | — | CN | claimed |
| US-20220313563-A1 | Storage-Stable Dental Adhesive Set For Use With Peroxidically And Hydroperoxidically Redox-Initiated Composites | IVOCLAR VIVADENT AG (LI) | 2022-10-06 | — | — | US | claimed |
| EP-4066811-A1 | STORAGE-STABLE DENTAL ADHESIVE KIT FOR USE WITH PEROXIDIC AND HYDROPEROXIDICALLY REDOX-INITIATED COMPOSITES | Ivoclar Vivadent AG (LI) | 2022-10-05 | — | — | EP | claimed |
| CN-115137518-A | Storage stable dental adhesive kit for use with peroxide and hydroperoxide redox initiated composite materials | 义获嘉伟瓦登特公司 | 2022-10-04 | — | — | CN | claimed |
| EP-0980233-B1 | METHOD AND COMPOSITION FOR ADHERING TO TOOTH STRUCTURE | DENTSPLY INT INC (US) | 2005-11-23 | — | — | EP | claimed |
| US-5621084-A | Process for removal of allyl group or allyloxycarbonyl group | PFIZER INC. (US) | 1997-04-15 | — | — | US | claimed |
| EP-0676236-A1 | Process for removal of allyl group or allyloxycarbonyl group | PFIZER INC. (US) | 1995-10-11 | — | — | EP | claimed |
| JP-58173175-A | — | — | None | — | — | JP | disclosed |
| US-20260144715-A1 | DENTAL CURABLE COMPOSITION HAVING HIGH MECHANICAL STRENGTH | SHOFU INC. (JP) | 2026-05-28 | — | — | US | disclosed |
| US-12622847-B2 | Organosilicon compound and dental composition containing same | KURARAY NORITAKE DENTAL INC. (JP) | 2026-05-12 | — | — | US | disclosed |
| EP-4717249-A1 | DENTAL COMPOSITION | Shofu Inc. (JP) | 2026-04-01 | — | — | EP | disclosed |
| EP-4717251-A2 | DENTAL CURABLE COMPOSITION HAVING HIGH MECHANICAL STRENGTH | Shofu Inc. (JP) | 2026-04-01 | — | — | EP | disclosed |
| US-20260083642-A1 | DENTAL COMPOSITION | SHOFU INC (JP) | 2026-03-26 | — | — | US | disclosed |
| EP-0676236-A1 | Process for removal of allyl group or allyloxycarbonyl group | PFIZER INC. (US) | 1995-10-11 | — | — | EP | disclosed |
| EP-0661034-A1 | Dental composition | TOKUYAMA CORPORATION (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-4740596-A | Process for preparation of 4-sulfonylthio azetidinone derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1988-04-26 | — | — | US | disclosed |
| US-4713452-A | Process for preparation of azetidinone derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1987-12-15 | — | — | US | disclosed |
| JP-S58173175-A | DENTAL ADHESIVE | KURARAY CO LTD | 1983-10-12 | — | — | JP | disclosed |
| US-4211676-A | Process for reclaiming scrap vulcanized rubber | BRIDGESTONE TIRE COMPANY LIMITED (JP) | 1980-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260144715-A1 | DENTAL CURABLE COMPOSITION HAVING HIGH MECHANICAL STRENGTH | CAD, SMCHD1, ITGA1 | EPHX1 2149/4885HPGD 1625/4885EPHX2 1771/4885 |
| US-12370129-B2 | Storage-stable dental adhesive set for use with peroxidically and hydroperoxidically redox-initiated composites | GPX4, VCL, ITGAV | EPHX1 1250/4885HPGD 754/4885EPHX2 1028/4885 |
| US-12622847-B2 | Organosilicon compound and dental composition containing same | MSL1, ITGA1, ITGAL | EPHX1 603/4885HPGD 2116/4885EPHX2 731/4885 |
| US-20260083642-A1 | DENTAL COMPOSITION | TAS2R42, COL2A1, TAS2R1 | EPHX1 2561/4885HPGD 1670/4885EPHX2 979/4885 |
| US-20220313563-A1 | Storage-Stable Dental Adhesive Set For Use With Peroxidically And Hydroperoxidically Redox-Initiated Composites | GPX4, VCL, ITGAV | EPHX1 1250/4885HPGD 754/4885EPHX2 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.