Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830849 | 0.92 | OPRM1 (0.38) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170643 | 0.82 | MTNR1A (0.40) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL12826657 | 0.80 | HCRTR1 (0.41) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL18473622 | 0.80 | HCRTR1 (0.40) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL13825005 | 0.79 | OPRM1 (0.36) | OPRM1OPRD1OPRK1 | |
| SCHEMBL12831142 | 0.79 | OPRM1 (0.36) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20170667 | 0.76 | OPRM1 (0.32) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170680 | 0.76 | HCRTR1 (0.38) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL12091332 | 0.74 | OPRM1 (0.37) | OPRM1OPRD1OPRK1 | |
| SCHEMBL13248810 | 0.74 | OPRM1 (0.37) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012008984-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2012-01-19 | — | — | WO | disclosed |