Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830849 | 0.84 | OPRM1 (0.38) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL10222575 | 0.82 | OPRM1 (0.37) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL12826657 | 0.78 | HCRTR1 (0.41) | OPRM1OPRD1OPRK1HCRTR1ALDH1A1 | |
| SCHEMBL18473622 | 0.76 | HCRTR1 (0.40) | OPRM1OPRD1OPRK1HCRTR1ALDH1A1 | |
| SCHEMBL20170757 | 0.75 | OPRD1 (0.54) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170667 | 0.74 | OPRM1 (0.32) | OPRM1OPRD1OPRK1HCRTR1ALDH1A1 | |
| SCHEMBL12091332 | 0.72 | OPRM1 (0.37) | OPRM1OPRD1OPRK1 | |
| SCHEMBL13248810 | 0.72 | OPRM1 (0.37) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20170680 | 0.72 | HCRTR1 (0.38) | OPRM1OPRD1OPRK1HCRTR1ALDH1A1 | |
| SCHEMBL13825005 | 0.71 | OPRM1 (0.36) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |