SCHEMBL10224841

SCHEMBL10224841

CCNCCSSCCOC(=O)CC

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NAAA Q02083 1/20 0.40
GAA P10253 2/20 0.33
HTT P42858 1/20 0.31
SAT1 P21673 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MGAM O43451 1/20 0.30
SI P14410 1/20 0.30
MGAM2 Q2M2H8 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP1A2 P05177 1/20 0.30
HPGD P15428 1/20 0.30
CYP2C19 P33261 1/20 0.30
BLM P54132 1/20 0.30
WRN Q14191 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15583422 0.84 NAAA (0.52) NAAAGAAHTTKDM4EMGAM
SCHEMBL13167886 0.83 NAAA (0.38) NAAAGAAKDM4E
SCHEMBL464486 0.82 SAT1 (0.31) SAT1
SCHEMBL19728773 0.81 HDAC3 (0.32) SAT1
SCHEMBL16892671 0.81 NAAA (0.48) NAAAGAAHTTSAT1KDM4E
SCHEMBL12110008 0.77 NAAA (0.45) NAAAGAAHTTKDM4EMGAM
SCHEMBL12110007 0.77 NAAA (0.45) NAAAGAAHTTKDM4EMGAM
SCHEMBL12103815 0.77 NAAA (0.45) NAAAGAAHTTKDM4EALDH1A1
SCHEMBL30566746 0.77 NAAA (0.55) NAAAGAAHTTSAT1ALDH1A1
SCHEMBL16256351 0.76 TSHR (0.52) NAAAGAAHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120225129-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS CERULEAN PHARMA INC. (US) 2012-09-06 US disclosed
US-20120213854-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS CERULEAN PHARMA INC. 2012-08-23 US disclosed
US-20110268658-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2011-11-03 US disclosed
US-20110262490-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2011-10-27 US disclosed
US-20110237686-A1 FORMULATIONS AND METHODS OF USE CERULEAN PHARMA INC (US) 2011-09-29 US disclosed
US-20100285144-A1 POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-11-11 US disclosed
US-20100247669-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-09-30 US disclosed
US-20100247668-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE CERULEAN PHARMA INC. 2010-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100247669-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 NAAA 1369/4885GAA 114/4885HTT 243/4885
US-20110268658-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 NAAA 1369/4885GAA 114/4885HTT 243/4885
US-20110262490-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 NAAA 1369/4885GAA 114/4885HTT 243/4885
US-20100247668-A1 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE LPXN, POLI, BRCA1 NAAA 1369/4885GAA 114/4885HTT 243/4885
US-20120213854-A1 METHODS OF TREATING A SUBJECT AND RELATED PARTICLES, POLYMERS AND COMPOSITIONS HLA-DRB1, TSG101, IAPP NAAA 3132/4885GAA 38/4885HTT 845/4885
US-20100285144-A1 POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE EPOR, TTPA, PDS5A NAAA 3379/4885GAA 391/4885HTT 18/4885
US-20110237686-A1 FORMULATIONS AND METHODS OF USE LPXN, LIPA, CHMP4B NAAA 1723/4885GAA 494/4885HTT 340/4885
US-20120225129-A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS SYNCRIP, EXOSC5, EXOSC9 NAAA 1722/4885GAA 869/4885HTT 156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.