SCHEMBL1022772

SCHEMBL1022772

CC(=O)Nc1cc(C)cc2nn[nH]c12

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 2/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
HSD17B10 Q99714 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
CHUK O15111 1/20 0.33
LMNA P02545 1/20 0.33
THRB P10828 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALOX15 P16050 1/20 0.33
GPR35 Q9HC97 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30843987 0.71 DHODH (0.35) KMT2AMEN1TDP1LMNAKDM4E
SCHEMBL9228666 0.70 GRIN2D (0.36) ALDH1A1KMT2AMEN1HSD17B10POLB
SCHEMBL1017993 0.67 ALDH1A1 (0.38) ALDH1A1TDP1POLBMAPTLMNA
SCHEMBL31667203 0.67 POLB (0.31) POLB
SCHEMBL24500838 0.67 XDH (0.36) ALDH1A1POLBMAPT
SCHEMBL23739980 0.67 ROCK2 (0.47) ALDH1A1HPGDKMT2AMEN1NPC1
SCHEMBL24629558 0.65 KDM4E (0.32) ALDH1A1POLBKDM4E
SCHEMBL29769180 0.65 KDM4E (0.32) ALDH1A1POLBKDM4E
SCHEMBL27753611 0.64 GAA (0.48) ALDH1A1HPGDKMT2AMEN1NPC1
SCHEMBL1247686 0.64 ROCK2 (0.55) ALDH1A1HPGDKMT2AMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121858-B1 AQUEOUS COATING COMPOSITION HAVING REDUCED PLATE OUT ARKEMA INC (US) 2013-10-16 EP disclosed
US-8450401-B2 Aqueous coating composition having reduced plate out ARKEMA INC. (US) 2013-05-28 US disclosed
US-8450402-B2 Method for reducing plate out of aqueous coating compositions ARKEMA INC. (US) 2013-05-28 US disclosed
EP-2121824-B8 METHOD FOR REDUCING PLATE OUT OF AQUEOUS COATING COMPOSITIONS ARKEMA INC (US) 2011-02-23 EP disclosed
EP-2121824-B1 METHOD FOR REDUCING PLATE OUT OF AQUEOUS COATING COMPOSITIONS ARKEMA INC (US) 2011-01-12 EP disclosed
US-20100324169-A1 AQUEOUS COATING COMPOSITION HAVING REDUCED PLATE OUT DOW GLOBAL TECHNOLOGIES, INC (US) 2010-12-23 US disclosed
US-20100319579-A1 METHOD FOR REDUCING PLATE OUT OF AQUEOUS COATING COMPOSITIONS ARKEMA INC. 2010-12-23 US disclosed
EP-2121858-A2 AQUEOUS COATING COMPOSITION HAVING REDUCED PLATE OUT DOW GLOBAL TECHNOLOGIES INC. (US) 2009-11-25 EP disclosed
EP-2121824-A2 METHOD FOR REDUCING PLATE OUT OF AQUEOUS COATING COMPOSITIONS DOW GLOBAL TECHNOLOGIES INC. (US) 2009-11-25 EP disclosed
WO-2008100608-A2 AQUEOUS COATING COMPOSITION HAVING REDUCED PLATE OUT DOW GLOBAL TECHNOLOGIES, INC (US) 2008-08-21 WO disclosed
WO-2008100607-A2 METHOD FOR REDUCING PLATE OUT OF AQUEOUS COATING COMPOSITIONS DOW GLOBAL TECHNOLOGIES, INC (US) 2008-08-21 WO disclosed