Biotin

Biotin

SCHEMBL1023525

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CC(S(=O)(=O)O)C(=O)N1O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.67
MEN1 O00255 1/20 0.67
ABL1 P00519 1/20 0.67
LMNA P02545 1/20 0.67
PKM P14618 1/20 0.67
IDE P14735 1/20 0.67
MAPK1 P28482 1/20 0.67
KMT2A Q03164 1/20 0.67
RIN1 Q13671 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
HLCS P50747 4/20 0.48
CA12 O43570 10/20 0.47
CA1 P00915 10/20 0.47
CA2 P00918 10/20 0.47
CA9 Q16790 10/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biotin SCHEMBL1270216 1.00 TDP1 (0.67) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL2192463 0.95 TDP1 (0.60) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1215022 0.84 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28780778 0.84 TDP1 (0.90) TDP1MEN1ABL1LMNAPKM
SCHEMBL29613855 0.84 TDP1 (0.57) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL4433162 0.83 TDP1 (0.87) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL1523072 0.83 TDP1 (0.71) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL28622397 0.82 TDP1 (0.67) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL486785 0.82 TDP1 (0.81) TDP1MEN1ABL1LMNAPKM
Biotin SCHEMBL437052 0.82 TDP1 (0.81) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023149585-A1 CELL LABELLING METHOD 国立研究開発法人理化学研究所 2023-08-10 WO claimed
EP-1883394-B1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2018-03-28 EP claimed
CN-117964767-A Anti-RAGE antibodies, extracellular vesicles, methods of making and uses thereof 北京恩泽康泰生物科技有限公司 2024-05-03 CN disclosed
WO-2023149585-A1 CELL LABELLING METHOD 国立研究開発法人理化学研究所 2023-08-10 WO disclosed
WO-2023143610-A2 C-TERMINAL FRAGMENT OF APOLIPOPROTEIN E AND APPLICATION THEREOF IN INHIBITING γ-SECRETASE ACTIVITY 斯莱普泰(上海)生物医药科技有限公司 2023-08-03 WO disclosed
EP-3625335-A1 IMMOBILIZED ENZYME COMPLEXES AND RELATED METHODS The Curators of the University of Missouri (US) 2020-03-25 EP disclosed
WO-2018213482-A1 IMMOBILIZED ENZYME COMPLEXES AND RELATED METHODS THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2018-11-22 WO disclosed
US-9572833-B2 Treatment of red blood cells THE GENERAL HOSPITAL CORPORATION (US) 2017-02-21 US disclosed
US-20140286921-A1 TREATMENT OF RED BLOOD CELLS THE GENERAL HOSPITAL CORPORATION 2014-09-25 US disclosed
EP-2776047-A1 TREATMENT OF RED BLOOD CELLS The General Hospital Corporation (US) 2014-09-17 EP disclosed
WO-2013070592-A1 TREATMENT OF RED BLOOD CELLS THE GENERAL HOSPITAL CORPORATION (US) 2013-05-16 WO disclosed
US-5703081-A CELL ADHESION INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-12-30 US disclosed
US-5536643-A Non-radioactive method for determining circulating red cell volume, total blood volume, and red cell survival BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) 1996-07-16 US disclosed
US-5519024-A CELL ADHESION INHIBITOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-21 US disclosed
EP-0614664-A1 Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-09-14 EP disclosed
EP-0484452-A1 FIBULIN LA JOLLA CANCER RESEARCH FOUNDATION (US) 1992-05-13 EP disclosed
WO-1991002755-A1 FIBULIN LA JOLLA CANCER RESEARCH FOUNDATION (US) 1991-03-07 WO disclosed
EP-0195009-B1 CHEMICALLY MARKED NUCLEIC ACIDS, UTILIZATION THEREOF AND KIT FOR ITS IMPLEMENTATION INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1989-09-06 EP disclosed
EP-0195009-A1 CHEMICALLY MARKED NUCLEIC ACIDS, UTILIZATION THEREOF AND KIT FOR ITS IMPLEMENTATION. INST NAT SANTE RECH MED (FR) 1986-09-24 EP disclosed
WO-1986000074-A1 CHEMICALLY MARKED NUCLEIC ACIDS, UTILIZATION THEREOF AND KIT FOR ITS IMPLEMENTATION INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M (FR) 1986-01-03 WO disclosed